Researchers from the University of Southern California and the Cleveland Clinic Center for Research and Innovation in
A chaperone protein known as GRP78 is involved in the spread of other viruses and plays an important role in the spread of SARS-CoV-2.
Chaperones are a class of proteins whose main function is to restore the correct native tertiary or quaternary structure of proteins, as well as the formation and dissociation of protein complexes.
Recently, scientists found that if you block the production of GRP78 or suppress its activity using a new targeted drug, this significantly reduces the replication of SARS-CoV-2.
To check if an “attack” on GRP78 will helpto treat COVID-19, researchers tested the newly identified small molecule drug HA15 on infected lung cells. It was originally developed against cancer cells. It specifically binds GRP78 and inhibits its activity.
Scientists have tested whether “suppression” worksanother GRP78 inhibitor, YUM70, in cancer. For this they used HA15. It turned out that HA15 and YUM70 suppress the production of mutant KRAS proteins (“responsible” for resistance to drug treatment) and reduce the viability of cancer cells.
Further research and clinical trials are needed to prove that HA15 and YUM70 are safe and effective in humans.
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