Revealed the cause of aging of human cells

A recent study by a team of scientists led by University of Montreal professor Francis Rodier

showed that cellular aging is caused not simply by damage to chromosome regions, but by irreversible defects in the genome. Learn more at

According to a study published byin Nucleic Acids Research, the human cell is aging as a result of damage to the genome, and the damage is irreversible. And this discovery goes against the theory of aging, which scientists adhered to earlier.

It was believed that telomeres (that is, "caps" onend of chromosomes; the main function of telomeres is to protect genetic information) with each division, cells are destroyed, and when they become too short, they "tell" the cell to stop division. In this case, the researchers thought, DNA is not damaged. As a result, after the cessation of division, the cell begins to age.

But it turned out that this cell division, associated with dysfunction of telomeres, is unstable. And this leads to genetic defects. In other words, senescent cells have an abnormal genome.

To conduct the research, a group of scientistsused the equipment due to which it was possible to recreate the process of cellular aging in the laboratory. It turned out that all telomeres of the cell population become dysfunctional.