Scientists create functional human blood cells using mice

Recently, research teams from Guangzhou Institute of Biomedicine and Health Care (GIBH) of China

Academy of Sciences (CAS) have made new progress instudy of interspecies chimerism with human pluripotent stem cells (hPSCs). They have developed enhanced hPSCs that, for the first time, make it possible to obtain functional human blood cells using cross-species chimerism technology.

Chimerism is the state in whichGenetically different cells coexist in the same organism. Many researchers are now exploring the possibility of using cross-species chimerism with hPSCs to obtain functional human cells, tissues, or organs in large animals. Scientists hope that this will solve the problem of shortage of donor tissues and organs. However, cross-species chimerism with hPSCs faces great hurdles due to the extremely low chimeric contribution of these important cells.

In a new study, researchers found thatrapid apoptosis of hPSCs in interspecies embryos was mainly associated with lack of growth and competition with host animal stem cells. The new MYCN factor in combination with the anti-apoptotic BCL2 gene effectively overcomes hPSC apoptosis and significantly promotes the formation of chimerism.

As a result, scientists managed to isolate livinghuman blood progenitor cells from mice using cross-species chimerism with hPSCs for complementation. The obtained samples can be further cultivated and differentiated into various blood cells.

Ultimately, improved hPSCs for cross-species chimerism will lead to advances in tissue and organ transplantation in the future, the scientists believe.

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