Scientists from Australia have proven that a specially developed form of fermentable fiber reduces
Doctors have long suspected that changesin the diet are important for the treatment of hypertension in patients. This method is known as DASH (Dietary Approach to Stop Hypertension) and has proven incredibly effective in lowering blood pressure in many patients.
However, exactly how DASH treats hypertension...it's still unclear. The most common hypothesis is that diet causes beneficial changes in the gut microbiome, increasing the production of short-chain fatty acids (SCFAs), which subsequently leads to improved blood pressure.
Francine Marquez from the School of Biological SciencesMonash University has been studying the relationship between these SCFA metabolites and blood pressure for several years. Previous preclinical studies have shown that acetate and butyric acids, in particular, reduce blood pressure in animal models. However, this approach requires patients to take SCFAs around the clock, making it unsuitable for humans.
Therefore, Marquez and his colleagues askedThe question is whether special fiber can be used to help gut bacteria deliver consistently high levels of beneficial SCFAs. In the experiment, the researchers used corn starch with a high amylose content, which can be modified to include acetate and butyric acids. They called the final product HAMSAB (English: acetylated and butyrylated high-amylose maize starch, acetylated and butyrylated corn starch with a high amylose content).
When gut microbes ferment HAMSAB,Large volumes of acetate and butyric acids are released into the colon. Scientists wanted to test whether HAMSAB supplements could effectively lower blood pressure in patients with hypertension.
“In hypertensive patients treated with HAMSAB,24-hour systolic blood pressure decreased by 6.1 mm Hg, the scientists said. “This is equivalent to one drug for lowering blood pressure and has important clinical implications.”
Blood tests showed that HAMSAB supplementsignificantly increased the level of acetate and butyric acid in the blood. These plasma levels were higher than could be achieved with standard dietary interventions.
Scientists also found that HAMSAB supplements changethe composition of the intestinal microbiome of each patient. According to Marquez, the study results support the hypothesis that SCFAs produced by the microbiome play a role in regulating human blood pressure.
The new study involved a small grouppeople, so there is still a lot of work to be done before such drugs become clinically available. As noted by the authors of the study, the results clearly demonstrate that modulating SCFA levels with the help of the gut microbiome can effectively treat hypertension.
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