According to the authors of the study, the method will be useful for identifying previously unrecognized changes in
The researchers separated the organs using a matrix,printed on a 3D printer. They created optimally sized tissue sections for optical imaging using 3D technology. To visualize virtually any cell type or protein of choice, scientists labeled parts of the organ. Because each piece of tissue has known coordinates, the individual 3D images are pieced together using a computer to form a 3D image.
This method allows the creation of high-resolution 3D images of human organs of almost any size. At the same time, micrometric accuracy is maintained.
Previously, scientists used opticalprojection tomography and light fluorescence microscopy to create precise, high-resolution images of biological material. But one problem was that previous methods did not offer a suitable way to label different types of cells or proteins for study.
Swedish researchers used a new methodto study the human pancreas. Inside it there are hundreds of thousands of cells that produce insulin - the islets of Langerhans. They play a key role in the production of insulin. When their production is disrupted, a person develops diabetes. Using the new method, the researchers have already demonstrated previously unknown features of the anatomy and pathology of the human pancreas, including areas with extremely high islet density.
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