Scientists have created the world's first complete map of the connections of the human immune system

Using advanced screening techniques to fine-tune the communication between individual cells, scientists created

the first complete map of the immune systemHumans. The new wiring will help researchers better understand how diseases such as cancer progress and develop the next generation of treatments. They will strengthen the body's defenses.

The project was implemented thanks to new databy transmitting signals between immune cells. Some of them patrol the body, looking for signs of injury or disease, and then send messages to others to join the fight. They are helped in this by proteins on the surface of immune cells that bind to receptor proteins on the surface of the others.

Some of these receptor connections were alreadyknown to science. But researchers from the Wellcome Sanger Institute and ETH Zurich have been actively working to create a more complete pattern of their distribution throughout the body. This was achieved through high-throughput screening of surface receptors. In this way, scientists were able to systematically map immune cell protein interactions on an unprecedented scale.

The wiring diagram details how immunecells interact throughout the body, and involves previously unknown contacts. This will provide scientists with valuable new information about how the body organizes immune defenses and will help develop treatments, such as improving cancer immunotherapy.

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