Scientists at the University of Michigan Rogel Cancer Center were delighted when they discovered
In collaboration with several laboratories, scientists produced a special nanoparticle. She “outsmarted” brain cancer and the results were even better than expected.
Nanoparticles delivered the inhibitor to the tumor inexperiments on mice. There, the drug successfully activated the immune system to destroy cancer. This process also triggered immune memory, so that the newly emerging tumor was also destroyed. This means the new approach could not only treat brain tumors, but also prevent or delay recurrences.
Small molecule inhibitor AMD3100 developedto block the action of CXCR12. It is a cytokine released by glioma cells. It creates a shield around the immune system, preventing it from being activated against the tumor. Researchers have shown in mouse models of glioma that AMD3100 prevents CXCR12 from binding to immunosuppressive myeloid cells. By neutralizing these cells, the immune system remains intact and can attack tumor cells.
“Nobody could get this molecule into the brain.This is truly a huge milestone, as outcomes for patients with glioma have not improved in the last 30 years,” explains Maria G. Castro, PhD, RC Schneider Collegiate Professor of Neurosurgery. Castro is the senior author of the study published in the journal ACS Nano.
Despite increased survival rates for many types of cancer, glioma remains a particularly dangerous cancer: only 5% of patients survive five years after diagnosis.
Gliomas are often resistant to conventional therapy, andthe environment inside the tumor suppresses the immune system, making new immune treatments ineffective. In addition, there is the problem of crossing the blood-brain barrier.
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