Scientists have grown 3D models of tumors in the laboratory

An international team of scientists has created a 3D model of a pancreatic cancer tumor in a laboratory. They

combined a bioengineering matrix and obtained frompatient cells that can be used to develop and test targeted treatments. For example, healthcare providers will be able to better understand how tumor cells grow in pancreatic cancer and respond to chemotherapy drugs.

Pancreatic cancer is very difficult to respond totreatment. The problem is that until the last moment there are practically no signs or symptoms of the disease. It can also be resistant to treatment, and the survival rate is lower compared to other types of cancer - only 5-10% after five years after diagnosis.

There are two main obstacles to treatmentpancreatic cancer - a very dense matrix of proteins and the presence of highly resistant cancer stem cells (CSCs) that are involved in recurrence and metastasis. Scientists have developed a matrix in which CSCs can interact with other types of cells and together behave in the same way as in the body. This gives researchers the opportunity to more realistically test different treatments.

Preclinical trials mainly rely ona combination of two-dimensional laboratory-grown cell cultures to predict response to treatment. However, conventional 2D cell cultures cannot mimic the key features of tumor tissues.

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