The authors of the new work believe that Aligheimer's disease may be associated with rather rare variations in
To do this, they completely decoded the DNA of more than two thousand carriers of Alzheimer's disease and their relatives, as well as almost 1.7 thousand people who were not related to each other by family ties.
Further, the authors compared sets of rare mutations andisolated from it 13 associated with the development of Alzheimer's disease. Many of the genes in which these mutations have been found are responsible for the formation of new synapses, the growth of neurons, and also control their plasticity.
Harvard University Professor Rudolph Tanzisaid that in the near future his team will study the effect of these mutations on the functioning of nerve cells and the entire nervous system as a whole: they will introduce similar DNA variations into the genome of stem cells and grow out of them miniature semblances of the brain.
Scientists hope that this will bring humanity closer to the creation of the first effective drugs for Alzheimer's disease.
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