The purposeful destruction of these genes led to the blockade of the exit and thus the death of the next one
Toxoplasma gondii is closely related to the pathogenmalaria Plasmodium falciparum. The parasite thus serves as a model organism for a tropical disease that kills hundreds of thousands of people worldwide every year.
We assume that such processescontrol the spread of the malaria pathogen,” explains Dr. Elena Jimenez-Ruiz, a parasitologist at the University of Munich. “Next, we explore what functions these proteins perform in the causative agent of malaria and whether there are possible starting points for developing new drugs.”
Toxoplasmosis is one of the mostcommon zoonoses in the world. It is an infectious disease that can be transmitted from cats to humans. People can also become infected by eating raw or undercooked meat. The infection is especially dangerous for pregnant women, as it can cause deformities of the fetus.
The causative agent of the disease is a unicellularparasite Toxoplasma gondii. Inside the host cell, it forms a small vesicle-like compartment called a parasitophoric vacuole that promotes nutrient exchange and synchronized cell division. The resulting daughter cells are connected to each other inside the vacuole by a network, something like an umbilical cord. Up to 64 daughter cells can form in a compartment. As soon as the offspring becomes mature, the regulatory mechanism causes the dissolution of the vacuole and the structures formed inside it. This is the moment when daughter cells become mobile and invade new host cells.
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