Scientists Improve Bone Bioprinting Using Growth Genes

The researchers used the gene encoding PDGF-B, a platelet-derived growth factor that

stimulates cell reproduction and migration. And the gene encoding BMP-2 is a bone morphogenetic protein that improves bone regeneration.  The authors delivered both genes using bioprinting.

Growth factors are necessary for productioncells. We use two different genes encoding two different growth factors. These growth factors help stem cells migrate to the defect area and form bone.

Ibrahim T. Ozbolat, Associate Professor, Department of Engineering Sciences and Mechanics

The authors of the work built the DNA for the protein into plasmids -these are loops of DNA that can carry genetic information. Once the DNA enters the progenitor cell, it begins to produce the right proteins to enhance bone growth.

Two genes were printed during surgery on a rat's skull. This was done using a device very similar to an inkjet printer. The mixture was created to increase gene activity.

In rats treated with printed genes, for sixweeks recovered about 40% of the bone tissue and 90% of the bone coverage. By comparison, normal rats recovered 10% of bone tissue and 25% of bone coverage.

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