Scientists understand how blood stem cells are born in mammals

Doctors from the University of New South Wales in Sydney have identified a mechanism in mice that

naturally usedin mammals, to produce blood from the cells lining blood vessels. This will lead to the fact that in the future, blood transfusions from strangers will not be required: it will be created from the cells that line the patient's blood vessels.

Scientists already know that embryosIn mammals, a process of endothelial to hematopoietic transition occurs, in which the cells lining blood vessels (endothelial cells) turn into blood stem cells. But the identity of the cells regulating this process still remained a mystery.

In a new study, scientistsidentified embryonic cells that can convert adult endothelial cells into blood stem cells. They used the mesoderm and found PDGFRA+ stromal cells derived from Mesp1 (Mesp1-derived PDGFRA+ stromal cells). It turned out that they regulate the appearance of hematopoietic stem cells in the dorsal aorta.

Although more research is needed,Before they can be used in clinical practice, the discovery will be useful in regenerative medicine. For example, providing a potential new tool for generating engraftable hematopoietic stem cells.

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