Doctors performed post-mortem autopsies on people who had suffered a severe form of coronavirus infection. Study
Scientists have used RNA sequencing tomeasurement of expression levels of various genes in tissue samples. The researchers assessed changes in gene expression profiles in the brains of COVID-19 patients and compared them to changes seen in uninfected people.
The results of the analysis showed that the genes thatusually activated with aging, for example, those associated with the functioning of the immune system also “turned on” with severe COVID-19. Conversely, regions of DNA that decrease in activity with age, such as those associated with synaptic activity, cognition and memory, also began to perform worse after infection.
Many patients who have had coronavirusinfection, the presence of neurological symptoms is reported even after recovery. For example, they complained of “brain fog,” memory loss, and trouble concentrating. The results of a new study reveal possible reasons for the changes and pave the way for the search for therapy.
We observed a significant association of cellular responseon DNA damage, mitochondrial function, regulation of stress response and oxidative stress, vesicular transport proteins, calcium homeostasis, and insulin signaling/secretion pathways previously associated with aging and brain aging.
Study authors
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