Stem cell researchers at the Weizmann Institute of Science in Israel have created synthetic mouse
A new study by Israeli scientists is based ontwo previous works of the group. The first work focused on reprogramming stem cells into a “naive” state, which allows them to differentiate into others. The scientists devoted the second experiment to the development of a device that will allow them to effectively grow embryos outside the uterus.
By combining these two methods, biologists grew oneone of the most advanced synthetic mouse embryos to date. They used naïve mouse stem cells that were cultured in a petri dish several years ago. They were divided into three groups that play a key role in embryo development.
Synthetic embryo in eight days of development. Photo: Weizmann Institute of Science
One group contained cells that would developinto embryonic organs. The other two types were treated with master regulatory genes from extraembryonic tissues—the placenta for one group and the yolk sac for the other. The three types of cells were then mixed together in an artificial womb that carefully controls pressure and oxygen exchange and gently moves samples to mimic the natural flow of nutrients.
Once inside, the three types of cells clump togethertogether to form embryo-like structures. As would be expected, the vast majority died at this stage, and only 0.5% - or 50 out of about 10,000 - successfully developed further.
Further research showed that the formThe internal structures and gene expression patterns of synthetic embryos correspond to natural ones with an accuracy of up to 95%. Their organs also seemed functional.
Read more:
Scientists filmed a strange creature with tentacles, which they mistook for a flower
On the moon, they found a place where the temperature is always comfortable for humans
AI has appeared that monitors processes and proposes new laws of physics