In the new work, biologists studied the consequences of this mutation. Scientists have previously discovered that she has
We are talking about the D614G mutation, which is found in almost all types of coronavirus on all continents of the Earth.
Experiments showed that the D614G mutation changedthe structure of the coronavirus shell proteins so that the chances of its successful binding to the ACE2 receptor and penetration into the cell have become higher. However, this same change gives antibodies more time and opportunity to bind to SARS-CoV-2 particles.
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In the course of the work, scientists have prepared several accuratevirtual models of coronavirus envelope proteins, with and without the D614G mutation. The researchers then used a supercomputer to simulate their interactions with ACE2 receptors on the surface of lung cells.
In addition to the fact that the virus has become more resistant to cold andspreads faster, it is more vulnerable to antibodies. The mutation provoked changes in the structure of proteins that are in the coronavirus shell.
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