The human brain appeared from three-dimensional cells: it will study methods of fighting cancer

The model consists of a ball of glioblastoma cells wrapped in a blood vessel. The latter was grown from

human endothelial cells. To reproduce the blood-brain barrier, the model has pericytes and astrocytes, two types of cells involved in the formation of the barrier.

The blood-brain barrier (BBB) ​​is a barrier that prevents neurotoxic plasma components, blood cells, and pathogens from entering the brain.

The idea is to test how various brain treatments will cross the BBB to deliver chemotherapy drugs to brain cancer cells.

To understand how well the model performs,the researchers experimented with nanoparticles they had developed themselves. They are coated with a peptide called AP2 which helps to pass through the barrier. Once inside, the particles release their payload — in this case, cisplatin, a common chemotherapy drug.

As a result, particles coated with AP2 couldreach the tumor and delivered a drug that kills cancer cells. Without the peptide coating, the particles tended to damage healthy blood vessels. The authors note that they have come up with a good approach, as the AP2 peptide also appears to help direct the nanoparticles to the tumor site by binding to the LRP1 receptor, which appears near tumors.

The team now plans to use this model to experiment with other drugs and other brain cancers.

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