The authors of the new work used the method of electroporation - this is a method of breaking the membranes of various cells to
This method is used in research laboratory activities, but today it requires voluminous and complex equipment. This feature limits its use for the administration of vaccines.
DNA vaccines are inexpensive, rapidly developed, and safe, but effective vaccination requires bulky and expensive electroporation devices.
Research text
The researchers proposed their adaptedmethod, in which all the work is done by a small device the size of a pen: when creating, the authors were inspired by an electronic barbecue lighter. Every time the lighter clicks, it generates a short pulse of electricity to ignite the flame.
Scientists took the design of a barbecue lighter and added a tiny spring-loaded mechanism inside it.
In addition to the lighter, the key innovation was the tightly positioned electrodes and the use of extremely short microneedles.
As a result, the authors created a small device that is comparable in functionality to bulky machines. It can be mass produced at low cost.
Combining a tiny electroporation pulse with microneedle electrodes created an efficient electrical interface with the skin and further reduced cost and complexity.
Research text
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