The microimplant measures the oxygen level in the tissues deep under the skin in real time

The device, which is smaller in size than the average ladybug and is powered by ultrasonic waves, will help

doctors monitor the condition of transplanted organs or tissues. In this way, it will provide early warning of potential problems after transplantation.

In addition, technology opens the way forcreating a variety of miniature sensors. They will be able to monitor other key biochemical markers in the body, such as pH or carbon dioxide. They will one day provide doctors with minimally invasive methods for monitoring the biochemistry within functioning organs and tissues.

Using ultrasound technology in combination with an integrated circuit, it is possible to create complex implants that penetrate very deep into tissue to obtain data from organs, the scientists note.

Diagram of an oxygen implant measuring 4.5 cm inlength and 3 cm wide. ΜLED, O2-sensitive film and optical filter make up the oxygen sensor and are controlled by an integrated circuit (IC). The piezoelectric crystal converts the electronic signal from the IC into ultrasonic waves that can be safely transmitted through living tissue. Credit: University of California, Berkeley, image by Soner Sonmezoglu.

Most methods for measuring tissue oxygenationprovide information only about what is happening at the surface of the body. They are based on electromagnetic waves that penetrate only a few centimeters under the skin or organ tissue. Although there are types of magnetic resonance imaging that provide information about deep tissue oxygen saturation, they take a long time and do not provide real-time data.

The new sensor is different from pulse oximeters,which are used to assess blood oxygen saturation. While they measure the proportion of hemoglobin in the blood, the device directly measures the amount of oxygen in the tissues.

The implant measures 4.5 cm long and 3 cm wideConsists of ΜLED, O2-sensitive film and optical filter. The device itself is controlled by an integrated circuit (IC). The piezoelectric crystal converts the electronic signal from the IC into ultrasonic waves, which are transmitted safely through living tissue.

One possible application of the sensor is monitoringtransplanted organs. The fact is that several months after transplantation, vascular complications may occur, which lead to graft dysfunction.

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