The severity of COVID-19 learned to predict by blood test

In the new work, the authors monitored the number of granulocytes - these are the most numerous representatives

leukocytes, about 50-80% of all white blood cells. Granulocytes are involved in the work of innate immunity.

Researchers at the Karolinska Institute studiedhow the diversity of granulocytes in the blood of patients changes: they used flow cytometry to determine specific immunotypes that would help predict the severity of infection.

The authors took blood from people who onlygot sick with a new type of coronavirus infection, and then repeated the procedure four months after discharge. They analyzed the state of granulocytes in those who had been ill at different stages and compared it with those in healthy people.

As a result, the authors found that severe infection is associated with increased levels of mature and immature neutrophils and decreased levels of eosinophils and basophils.

Our research reveals a significant changecharacteristics of all granulocyte subtypes in patients with COVID-19. This may be related to the severity of the disease. By measuring the characteristics of granulocytes, as well as determining the presence of widely used biomarkers such as C-reactive protein and creatinine, it is possible to predict the main clinical features of the infection, for example, respiratory function and the development of multiple organ failure.

Magda Lourdes, lead author of the study

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