There are several reasons why TB goes undetected in infants and toddlers. Firstly,
Second, children may have problems obtaining sputum samples. It is in them that bacteria are found Mycobacterium tuberculosis (Koch's bacillus), which cause tuberculosis... And since the number of bacteria in a child's sample is often much less than that of an adult, routine testing can be inaccurate.
Scientists from Tulane University in New Orleans(USA) developed a blood test that checks for the presence of CFP-10 protein. It is secreted by bacteria and may be present in the bloodstream up to 60 weeks before a child develops tuberculosis. Only a small blood sample is required. The fact is that antibodies are manifested to enrich any CFP-10. This allows it to show up better when analyzed with a mass spectrometer.
A blood test checks for the presence of a control protein produced by the tuberculosis-causing Mycobacterium tuberculosis (pictured)
The results of the experiment showed that the newthe analysis is 100% accurate in identifying patients diagnosed with TB using gold standard testing methods. In addition, he also identified 83.7% of children in whom tuberculosis was not detected using traditional tests, but who were later diagnosed with the disease by doctors.
The study is described in an article published in the journalBMC Medicine.
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