There was a simple way to create lung tissue. It will study medicines and diseases

As tissue develops, it forms a three-dimensional structure with tiny hairs on the surface: this is typical of

lung tissue. According to the authors, such organoids can play an important role in research on lung disease, as well as help in the development of drugs and personalized treatment.

The method we have created for growing lung tissue is simple and inexpensive. At the same time, organelles reproduce well all important biological aspects.

Peter Valentek, doctor and lead researcher

The study was led by researchers from the CaliforniaUniversity of San Francisco, USA, in close collaboration with researchers from Freiburg. The authors combined lung cells with two messengers after two weeks of cultivation in the laboratory. Next came the organelles.

Previously, this process included manystages. For example, cells that have been removed must first be brought into an embryonic state using sophisticated techniques. In addition, the outer part of the tissue in such organoids was always directed inward and was much less similar to the natural model.

In the future, this simple method will allow us to grow tissues from individual patients in the lab to test in advance whether the therapy is effective or not.

Peter Valentek, doctor and lead researcher

Also, scientists can use the organoid toexplore how healthy lung tissue develops and how exactly genetic changes affect, for example, the formation of tiny hair-like structures.

These structures are called cilia.Malformation of cilia leads not only to lung diseases, but also to genetic diseases of the kidneys, which we are investigating at the NEPHGEN Collaborative Research Center (SFB1453).

Peter Valentek, doctor and lead researcher

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