Tiny sensor monitors the propagation of light in deep brain tissue

Engineers at the Massachusetts Institute of Technology (MIT) have developed a sensor that convertsSvetv

magnetic signal.Using this device and MRI, it is possible to track the propagation of light deep in tissue, such as inside the brain. The development will be useful in biological and medical research.

To create a light sensorengineers put the magnetic particles into a nanoparticle called a liposome. This is a biological structure, which is a microscopic vesicle surrounded by one or more lipid membranes.

The scientists used special liposomes,coated with photosensitive lipids (bioorganic substances). Under the influence of light of a certain wavelength, liposomes become permeable to water or "leaky". As a result, magnetic particles placed inside the "bubble" begin to interact with water and generate a signal that is detectable by MRI.

Depending on the type of lipids used,the permeability of particles changes under the influence of light with different wavelengths. For example, in a new study, scientists created sensors that activated when exposed to ultraviolet light and became “tight” to blue light.

The researchers tested the sensors in a stripedThe body of the rat brain is the part of the central nervous system responsible for planning movements and responding to rewards. After introducing the particles, the scientists mapped the distribution of light from an optical fiber implanted nearby.

Scientists note that light is actively usedfor the study of tissues and the functioning of organs, as well as for treatment, for example, in light therapy of oncological formations. But visualizing light in deep tissues is extremely difficult. As light enters tissues, most of it is either absorbed or scattered. The ability to accurately understand how light propagates within tissues will increase the effectiveness of research and therapy, the authors conclude.

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Cover image: iStock, MIT