Immunotherapy has revolutionized the treatment of cancer, however, the vast majority of patients do not experience
That's why we focused on vaccines: they usually combinetumor-specific targets that the immune system can learn to recognize and attack to prevent cancer recurrence.The vaccine also contains a dijuvant that stimulates the immune system to maximize efficacy.Thomas Marron, MD, Assistant Director for Early Phase and Immunotherapy Trials at Tisch Cancer Institute
To create a personalized vaccine againstcancer, Dr. Marron and his colleagues sequenced tumor and germline DNA and tumor RNA from each patient. They also identified a patient's tumor target to help predict whether the immune system will recognize the vaccine.
The Mount Sinai Computing Platform enables researchers to identify and prioritize immunogenic targets for synthesis and vaccine incorporation.
Most experimental personalizedCancer vaccines are administered in metastatic settings, but previous studies show that immunotherapy tends to be more effective in patients with less spread cancer, said Nina Bhardwaj, MD, director of the Immunotherapy Program and Ward-Coleman Chair in Cancer Research at the Cancer Institute. Tish on Mount Sinai.
Therefore, the authors have developed a neoantigen vaccine,which is administered after standard adjuvant therapy such as surgery: it is necessary for solid tumors, bone marrow transplantation, and multiple myeloma.
The results show that the pipeline is great at helping to create a safe, personalized cancer vaccine that could potentially be used to treat a range of tumor types.
After monitoring patients for 880 daysfour patients showed no signs of cancer, four continued to receive therapy, and four died. The vaccine was well tolerated and about a third of patients developed mild injection site reactions.
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