Scientists used the gene-editing tool CRISPR to turn white fat "beige." Then they
Fat sucked from the bodyand modified using the gene editing tool CRISPR, can be used to treat cancer. However, it remains to be seen whether the experimental therapy will be safe and effective in humans.
New research has found that white fat extracted from the body can be genetically reprogrammed to mimic brown fat and then injected into rodents to reduce tumors.
Brown adipose tissue is one of two types of fattissues in mammals. Brown fat is well developed in newborns and in hibernating animals. In adults, brown adipose tissue is present and metabolically active, but it regresses with age.
White fat stores excess energyin the body, and brown heats the body, destroying blood sugar or glucose. This feature can be used to deprive tumors of the nutrients they need to grow. The study tested this idea using white fat extracted from both humans and mice, as well as tumors transplanted from humans and mice.
University of California staffSan Francisco tested adipose modulation transplantation (AMT) in mouse models of breast, colon, pancreatic and prostate cancer and found that implanting brown fat resulted in all of these tumors shrinking to half their size.
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