Non-invasive sonic technology developed at the University of Michigan destroys liver tumors in
Destroying only 50% to 75% of the tumor volumeliver, the immune system of rats was able to get rid of the rest without signs of recurrence or metastases in more than 80% of the animals. “The method reduces the risk of future metastasis,” explains Zhen Xu, professor of biomedical engineering at the University of Michigan and author of the study.
The results also showed that the treatment stimulated the immune responses of the rats, possibly contributing to the eventual regression of the off-target part of the tumor and preventing further spread of the cancer.
In many difficult clinical situations, the entire cancerous tumor cannot be removed in the usual way. This is influenced by the size of the formation, its location or stage of development.
To solve the problem, scientists have improved the methodhistotripsy (use of high intensity ultrasound). They created a special transducer that delivers high-amplitude ultrasonic pulses of microsecond duration. As a result, they focus on the tumor specifically for its destruction. Conventional ultrasound devices use lower amplitude pulses for imaging.
Long microsecond pulses from the new sensorgenerate microbubbles in target tissues that quickly expand and collapse. These strong but extremely localized mechanical stresses kill cancer cells and destroy the tumor structure.
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